Trimethoprim

 
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Structure

Trimethoprim DS Tablets
Each tablet contains Trimethoprim IP 160 and Sulphamethoxazole IP 800 mg

Trimethoprim Suspension
Each 5 ml contains Trimethoprim IP 40 and Sulphamethoxazole IP 200 mg

Without a Prescription

Trimethoprim is prescribed for the treatment of:
- Acute exacerbations of chronic bronchitis in adults;
- Acute otitis media in paediatric patients;
- Pneumocystis carinii pneumonia;
- Traveller's diarrhoea in adults;
- Urinary tract infections;

Dosage

Trimethoprim should be taken with fluid, preferably after a meal.
Adequate fluids should be taken when on Trimethoprim.
The patient should notify the physician of skin rash, sore throat, fever or unusual bruising or bleeding.

Adults and children (above 12 years)
Contraindicated in pediatric patients less than 2 months of age.
Urinary Tract Infections and Shigellosis in adults and pediatric patients and acute otitis media in pediatric patients.

Adults
The usual adult dosage in the treatment of urinary tract infections is 1 Trimethoprim DS tablet, or 4 teaspoonful Trimethoprim suspension every 12 hours for 10 to 14 days.
An identical dosage is used for 5 days in the treatment of Shigellosis.

Acute Exacerbation of Chronic bronchitis
1 Trimethoprim DS, or 4 teaspoonful of Trimethoprim suspension every 12 hours for 14 days.

Travelers Diarrhoea
1 Trimethoprim DS tablet, or 4 teaspoonful of Trimethoprim suspension every 12 hours for 5 days.

Pediatric patients
The recommended dose for pediatric patients with urinary tract infections and acute otitis media is 8 /kg trimethoprim and 40 mg/kg sulfamethoxazole per 24 hours, given in two divided doses every 2 hours for 10 days.
An identical daily dosage is used for 5 days in the treatment of Shigellosis.
The following table is a guideline for the attainment of this dosage.

Pneumocyst carinii pneumonia: Treatment
Adults and Paediatric Patients
The recommended dosage for treatment of patients with documented
Pneumocystis carinii pneumonia is 15 to 20 /kg trimethoprim and 75 to 100 mg/kg sulfamethoxazole per 24 hours given in equally divided doses every 6 hours for 14 to 21 days.

Prophylaxis
Adults
1 Trimethoprim DS tablet daily.
Paediatric patients
The recommended dose is 150 /m 2 /day trimethoprim with 750 mg/m 2 / day sulfamethoxazole given orally in equally divided doses twice a day, on 3 consecutive days per week.
The total daily dose should not exceed 320 trimethoprim and 1,600 mg sulfamethoxazole.

Contraindications

Trimethoprim is contraindicated if you have any of the following conditions:
- Blood dyscrasias;
- Known hypersensitivity to sulphonamides and/or trimethoprim;
- Marked liver parenchymal damage;
- Severe renal insufficiency and glucose 6-phosphate dehydrogenase deficiency;

Treatment must be discontinued on the appearance of a skin rash, or if any element of the blood count is reduced.

Package

- Blister pack of 10 tablets;
- Suspension bottle of 60 ml;
Without Prescription (2017)