Tranexamic-Acid

 
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Structure

Each film coated tablet contains Tranexamic Acid BP… 500 mg.

Without a Prescription

Gynaecology and obstetrics:
Menorrhagia
IUCD-induced menstrual blood loss
Bleeding associated with pregnancy
Conisation of the cervix

Acute gastrointestinal bleeding

Oral surgery:
Patients receiving anticoagulant therapy
Patients with haemophilia

Cardiac surgery with cardiopulmonary bypass (CPB)

Other surgery:
Urinary tract surgery
Orthopaedic surgery

Ocular trauma
Hereditary angioneurotic oedema
Epistaxis

Dosage

For local fibrinolysis
1-1.5 gm orally 2 to 3 times daily 500 - 1gm slow IV inj. 3 times daily

For generalised fibrinolysis
1 gm slow IV inj. at the rate of 1 ml/min 3 to 4 times daily

Children
Oral dose: 25 /kg 2 to 3 times daily
IV dose: 10 /kg 2 to 5 times daily

Elderly patients
No reduction in dosage is necessary

SPECIFIC INDICATIONS
1. Menorrhagia
1 to 1.5 gm orally 3 to 4 times daily for 3 to 4 days

2. Prostatectomy
500 to 1 gm 3 times, perioperative IV inj.
Followed by 1 gm 3 to 4 times daily until macroscopic haematuria is no longer present

3. Upper GI bleeding
4.5 to 6 gm daily, divided into 3 to 6 doses, for 5 to 7 days

4. Dental surgeries with coagulopathics
1 to 1.5 gm orally 3 times daily with haemophilia or 4.8 to 5% w/v mouthwash for two minutes 4 times daily for 7 days in patients receiving oral anticoagulants

5. Conisation of the cervix
1 to 1.5 gm orally 3 times daily for 12-14 days post operatively

6. Cardiac surgery with CPB
IV dose of 10 /kg given over 20 to 30 mins before the surgery followed by 1 mg/kg/hr during CPB

7. Orthopaedic Surgery
10-15 /kg IV infusion before release of tourniquet, with 1 or 2 further doses at 3 hours interval if necessary in knee replacement therapy

8. Ocular Trauma
1 to 1.5 gm orally 3 times daily in traumatic hyphaema

9. Hereditary angineurotic oedema
1.5 gm 3 times daily

10. Epistaxis
1 to 1.5 gm 3 times daily for 4 to 10 days

Contraindications

Tranexamic-Acid is contraindicated if you have any of the following conditions:
Tranfib tablets and injection are contraindicated:
1. In patients with active intravascular clotting process (primary fibrinolysis must be differentiated from disseminated intravascular coagulation)
2. In patients with acquired defective colour vision (used as an indicator of toxicity)
3. In patients with sub-arachnoid haemorrhage (potential occurrence of cerebral ischaemic complications)
4. Hypersensitivity to tranexamic acid
5. Severe renal insufficiency

Package

- Blister pack of 10 tablets;
Without Prescription (2017)