Tolbutamide

 
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Without a Prescription

Diabetes occurs when the body does not make enough insulin, or when the insulin that is produced no longer works properly.
Insulin works by helping sugar get inside the body's cells, where it is then prescribed for energy.
Tolbutamide can be combined with metformin (Glucophage) or insulin in order to get better results.
Tolbutamide controls diabetes by stimulating the pancreas to secrete more insulin and by helping insulin work better.
Tolbutamide is a medicine that should be regularly accompanied by diet and exercise.
Tolbutamide is an oral antidiabetic medication.
Tolbutamide is prescribed to treat patients who are suffering from type 2 diabetes.
Tolbutamide is prescribed to treat type 2 (non-insulin-dependent) diabetes.
There are two forms of diabetes: type 1 (insulin-dependent) and type 2 (non-insulin-dependent).
Type 1 diabetes usually requires taking insulin injections for life, while type 2 diabetes can usually be treated by dietary changes, exercise, and/or oral antidiabetic medications such as Tolbutamide.

Side Effects

Tolbutamide side effects that you should report to your health care professional or doctor as soon as possible:
- And nerve damage;
- Anemia and other blood disorders;
- Anxiety;
- Blistering;
- Bloating;
- Caused by excessive levels of a substance called porphyrin in the liver);
- Changes in taste;
- Cold sweat;
- Cold sweats;
- Coma;
- Cool skin;
- Difficulty concentrating;
- Drowsiness;
- Fast heartbeat;
- Headache;
- Heartburn;
- Hepatic porphyria (a condition frequently characterized by sensitivity to light;
- Hives;
- Increased hunger;
- Increased thirst;
- Increased urination;
- Itching;
- Nausea;
- Nervousness;
- Pale skin;
- Redness of the skin;
- Seizures;
- Shaking;
- Shallow breathing;
- Skin eruptions;
- Skin rash;
- Stomach pain;

Contraindications

Tolbutamide is contraindicated if you have any of the following conditions:
- A severe illness, infection, or injury;
- If you are elderly, run-down, malnourished, hungry, exercising heavily, drinking alcohol, or using more than one glucose-lowering drug;
- If you are suffering from diabetic ketoacidosis;
- If you have a heart condition;
- If you have a lack of adrenal or pituitary hormone;
- If you have had an allergic reaction to it;
- If you suffer from a kidney or liver problem;
- Kidney disease;
- Liver disease;
- Thyroid disease;
- To undergo surgery;
- Type 1 diabetes;

Interactions

Do not take Tolbutamide with any of the following drugs:
- Thyroid medications such as synthroid;
- Thiazide and other diuretics such as diuril and hydrodiuril;
- Sulfa drugs such as bactrim and septra;
- Rifampin (rifadin);
- Probenecid (benemid);
- Phenytoin (dilantin);
- Oral contraceptives;
- Nonsteroidal anti-inflammatory agents such as advil, aspirin, motrin, naprosyn, and voltaren;
- Niacin (nicobid, nicolar);
- Miconazole (monistat);
- Methyldopa (aldomet);
- Mao inhibitors such as nardil and parnate;
- Major tranquilizers such as stelazine and mellaril;
- Itraconazole (sporanox);
- Isoniazid (nydrazid);
- Furosemide (lasix);
- Fluconazole (diflucan);
- Estrogens (premarin);
- Epinephrine (epipen);
- Colestipol (colestid);
- Clofibrate (atromid-s);
- Cimetidine (tagamet);
- Chloramphenicol (chloromycetin);
- Calcium channel blockers such as cardizem and procardia;
- Blood-thinning drugs such as coumadin;
- Beta blockers such as inderal and tenormin;
- Barbiturates such as amytal, seconal, and phenobarbital;
- Anabolic steroids such as testosterone;
- Airway-opening drugs such as proventil and ventolin;
- Adrenal corticosteroids such as prednisone (deltasone) and cortisone (cortone);

Dosage

CHILDREN

Safety and effectiveness have not been established in children.

ADULTS

Maintenance therapy usually ranges from 0.25 to 3 grams daily.
Usually an initial daily dose of 1 to 2 grams is recommended.
Daily doses greater than 3 grams are not recommended.

OLDER ADULTS

Older, malnourished, or debilitated people, or those with impaired kidney or liver function, are usually prescribed lower initial and maintenance doses to minimize the risk of low blood sugar (hypoglycemia).

Overdose

Reported Tolbutamide overdose symptoms are:
- Anxiety;
- Cold sweats;
- Coma;
- Drowsiness;
- Hunger;
- Nausea;
- Unconsciousness;
- Weakness;

Other Brand Names


- Arcosal;
- Artosin;
- Diabetol;
- Diatelan;
- Diatol;
- Dirastan;
- Flusan;
- Glyconon;
- Ipoglusan;
- Novobutamide;
- Tolbutamide Diagnostic;
- Rastinon;
- Tolbutamide;
Without Prescription (2017)