Without a Prescription

Tofranil is prescribed to treat depression.
Tofranil is prescribed to patients who are suffering from depression.
Tofranil is prescribed on a short term basis, along with behavioral therapies, to treat bed-wetting in children aged 6 and older.
Tofranil is a member of the family of drugs called tricyclic antidepressants.
Tofranil belongs to a wide class of medicines that have been called tricyclic antidepressants.
This type of drugs is known to affect some brain chemicals (prevent them from becoming unbalanced).
Its effectiveness may decrease with longer use.

Tofranil is prescribed to treat:
- Attention deficit disorder in children;
- Bulimia;
- Obsessive-compulsive disorder;
- Panic disorder;

Side Effects

Tofranil side effects that you should report to your health care professional or doctor as soon as possible:
- Weight changes;
- Weakness;
- Unusual weight gain, swelling;
- Unpleasant taste, dry mouth;
- Swelling of breasts;
- Swelling due to fluid retention (especially in face or tongue);
- Sweating;
- Sudden weakness or numbness;
- Stroke;
- Stomach upset;
- Sore throat;
- Skin itching and rash;
- Sensitivity to light;
- Seizures;
- Ringing in the ears;
- Restlessness;
- Rapid heartbeat;
- Purple or reddish-brown spots on skin;
- Pounding, uneven or fast heart beat;
- Palpitations;
- Odd taste in mouth;
- Nightmares;
- Nausea;
- Nausea, stomach pain, vomiting, loss of appetite;
- Loss of appetite;
- Light-headedness (especially when rising from lying down);
- Lack of coordination;
- Lack of coordination;
- Irregular heartbeat;
- Intestinal blockage;
- Insomnia;
- Inflammation of the mouth;
- Increased or decreased sex drive;
- Impotence;
- Impotence, decreased sex drive;
- Hives;
- High pressure of fluid in the eyes;
- High or low blood sugar;
- High blood pressure;
- Heavy feeling or chest pain, pain spreading to the shoulder or arm, sweating, nausea, general illness;
- Heart failure;
- Heart attack;
- Headache;
- Headache, blurred vision, ringing in the ears;
- Hallucinations;
- Hallucinations, confusion, or seizures;
- Hair loss;
- Frequent urination or difficulty or delay in urinating;
- Flushing;
- Fever;
- Feeling drowsy, dizzy, or tired;
- Fatigue;
- Extreme thirst with nausea, headache, weakness and vomiting;
- Excessive or spontaneous flow of milk;
- Episodes of elation or irritability;
- Easy bleeding or bruising, abnormal weakness;
- Dry mouth;
- Drowsiness;
- Dizziness;
- Disorientation;
- Dilated pupils;
- Diarrhea or constipation;
- Delusions;
- Cough;
- Constipation or diarrhea;
- Congestive heart failure;
- Confusion;
- Confusion, sudden headache, problems with speech, vision, or balance;
- Bruising, skin rash, pain, numbness, severe tingling, or muscle weakness;
- Breath shortness;
- Breast swelling;
- Breast development in males;
- Blurred vision;
- Blood disorders;
- Bleeding sores;
- Black tongue;
- Anxiety;
- Agitation;
- Abdominal cramps;


Tofranil is contraindicated if you have any of the following conditions:
- A history of stroke, heart attack, or seizures;
- Bipolar disease (also known as manic-depression);
- Diabetes;
- Glaucoma;
- Heart disorder;
- Liver or kidney disorder;
- Overactive thyroid;
- Pheochromocytoma;
- Urination problems;
- If you are recovering from a recent heart attack;
- If you are sensitive or allergic to it;
- If you have or have ever had: narrow-angle glaucoma (increased pressure in the eye); difficulty in urinating; heart, liver, kidney, thyroid disease; seizures;


Do not take Tofranil with any of the following drugs:
- Cimetidine (tagamet);
- Clonidine (catapres);
- Guanethidine (ismelin);
- Heart rhythm drugs;
- Methylphenidate (ritalin, concerta, daytrana);
- Albuterol (proventil, ventolin);
- Antidepressants that act on serotonin, including prozac, paxil, and zoloft;
- Barbiturates such as nembutal and seconal;
- Blood pressure medications such as ismelin, catapres, and wytensin;
- Carbamazepine (tegretol);
- Cimetidine (tagamet);
- Decongestants such as sudafed;
- Drugs that control spasms, such as cogentin;
- Epinephrine (epipen);
- Flecainide (tambocor);
- Major tranquilizers such as mellaril and thorazine;
- Methylphenidate (ritalin);
- Norepinephrine;
- Other antidepressants such as elavil and pamelor;
- Phenytoin (dilantin);
- Propafenone (rythmol);
- Quinidine (quinaglute);
- Thyroid medications such as synthroid;
- Tranquilizers and sleep aids such as halcion, xanax, and valium;



People in these two age groups should take lower doses. Dosage starts out at 30 to 40 mg per day and can go up to no more than 100 mg a day.


Tofranil is not to be used in children to treat any condition but bedwetting, and its use will be limited to short-term therapy. Safety and effectiveness in children under the age of 6 have not been established.

Total daily dosages for children should not exceed 2.5 mg for each 2.2 pounds of the child's weight.

Doses usually begin at 25 mg per day. This amount should be taken an hour before bedtime. If needed, this dose may be increased after 1 week to 50 mg (ages 6 through 11) or 75 mg (ages 12 and up), taken in one dose at bedtime or divided into 2 doses, 1 taken at mid-afternoon and 1 at bedtime. ADULTS The usual starting dose is 75 mg a day. The doctor may increase this to 150 mg a day. The maximum daily dose is 200 mg.


Reported Tofranil overdose symptoms are:
- Agitation;
- Blue fingernails or lips;
- Bluish skin;
- Blurred vision;
- Breath shortness;
- Coma;
- Coma;
- Convulsions;
- Difficulty breathing;
- Dilated pupils;
- Drowsiness;
- Extreme drowsiness;
- Fainting;
- Heart failure;
- High fever;
- Involuntary writhing or jerky movements;
- Irregular or rapid heartbeat;
- Lack of coordination;
- Light-headedness;
- Low blood pressure;
- Muscle stiffness;
- Overactive reflexes;
- Restlessness;
- Rigid muscles;
- Seizure (convulsions);
- Shock;
- Stupor;
- Sweating;
- Swelling;
- Uneven heartbeats;
- Vomiting;

Other Brand Names

- Berkomine;
- Celamine;
- Depramina;
- Elepsin;
- Ethipramine;
- Fixon;
- Imipra;
- Imipramine;
- Medipramine;
- Novo-Pramine;
- Praminan;
- Pryleugan;
- Sermonil;
- Talpramin;
- Tofranil;
Without Prescription (2017)