Thioguanine

 
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Without a Prescription

Thioguanine belongs to a class of drugs known as purine antagonists.
Thioguanine is a chemotherapy drug.
Thioguanine is prescribed along with other drugs to treat a certain type of cancer (acute nonlymphocytic leukemia).
Thioguanine is prescribed to treat some leukemias.
Thioguanine works by slowing or stopping the growth of cancer cells.

Side Effects

Thioguanine side effects that you should report to your health care professional or doctor as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- breathing problems;
- Dark urine;
- Diarrhea;
- Dizziness/fainting;
- Easy bruising/bleeding;
- Itching/swelling (especially of the face/tongue/throat);
- Joint pain/swelling;
- loss of appetite;
- low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. you may be at increased risk for infections and bleeding;
- mouth sores;
- nausea, vomiting;
- Nausea;
- Persistent nausea/vomiting;
- Rash;
- right upper belly pain;
- Severe dizziness;
- signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine;
- signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness;
- signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine;
- Stomach/abdominal pain;
- swelling of the ankles, feet, hands, or stomach;
- Tongue/mouth sores or pain;
- Trouble breathing;
- Unusual tiredness;
- Upset stomach;
- Vomiting;
- water or weight gain;
- Yellowing eyes/skin;
- yellowing of the eyes or skin;

Contraindications

Thioguanine is contraindicated if you have any of the following conditions:
- an unusual or allergic reaction to thioguanine, other chemotherapy, other medicines, foods, dyes, or preservatives;
- breast-feeding;
- infection (especially virus infection such as chickenpox or herpes);
- liver disease;
- low blood counts like low platelets, red blood cells, or white blood cells;
- pregnant or trying to get pregnant;
- thiopurine methyltransferase (tpmt) deficiency;
- if you are allergic to thioguanine;
- if you have any other allergies;
- if you have gout;
- if you have kidney stones;
- if you have liver disease;
- if you have other blood disorders (anemia, low blood cell counts);

Interactions

Do not take Thioguanine with any of the following drugs:
- acetaminophen;
- Aminosalicylates;
- Amiodarone;
- aspirin;
- Azathioprine;
- balsalazide;
- Busulfan;
- Drugs that contain trimethoprim;
- Drugs that may affect bone marrow;
- Drugs that may affect the liver;
- Erythromycin;
- ibuprofen;
- ketoprofen;
- medicines that treat or prevent blood clots like warfarin;
- medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim;
- mesalamine, 5-asa;
- Mesalazine;
- naproxen;
- Olsalazine;
- Other anti-cancer drugs;
- sulfasalazine;
- Sulphasalazine;
- vaccines;

Overdose

Reported Thioguanine overdose symptoms are:
- Diarrhea;
- Nausea;
- Unusually heavy sweating;
- Vomiting;
Without Prescription (2017)