Without a Prescription

Sulindac is a non-steroidal anti-inflammatory drug (NSAID). Sulindac is prescribed to reduce swelling and to treat pain. Sulindac is prescribed for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout.
Sulindac is prescribed to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine).
Sulindac is in a class of medications called NSAIDs.
Sulindac is prescribed to relieve gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints).
Sulindac is prescribed to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone).
Sulindac works by stopping the body's production of a substance that causes pain, fever, and inflammation.


Sulindac is contraindicated if you have any of the following conditions:
- Asthma, especially aspirin sensitive asthma;
- Coronary artery bypass graft (CABG) surgery within the past 2 weeks;
- Drink more than 3 alcohol containing drinks a day;
- Heart disease or circulation problems like heart failure or leg edema (fluid retention);
- High blood pressure;
- Kidney disease;
- Liver disease;
- Stomach bleeding or ulcers;
- An unusual or allergic reaction to Sulindac, aspirin, other NSAIDs, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
- Breast-feeding;
- Tell your doctor and pharmacist if you are allergic to Sulindac, aspirin or or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), or any other medications.
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik)angiotensin II receptor antagonists such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), valsartan (Diovan) cyclosporine (Neoral, Sandimmune) diuretics ('water pills') lithium (Eskalith, Lithobid) oral medications for diabetes methotrexate (Rheumatrex) and probenecid (Benemid).
- Tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose) kidney stones swelling of the hands, arms, feet, ankles, or lower legsor liver or kidney disease.
- Tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking Sulindac, call your doctor.


Do not take Sulindac with any of the following drugs:
- Cidofovir;
- Ketorolac;
- Methotrexate;
- Pemetrexed;
- Alcohol;
- Aspirin and aspirin-like drugs;
- Cyclosporine;
- Diflunisal;
- Dimethyl sulfoxide, DMSO;
- Diuretics;
- Lithium;
- Drugs for diabetes;
- Drugs for high blood pressure;
- Drugs that affect platelets;
- Drugs that treat or prevent blood clots like warfarin;
- NSAIDs, drugs for pain and inflammation, like ibuprofen or naproxen;
- Probenecid;
- Steroid drugs like prednisone or cortisone;

Side Effects

Sulindac side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Changes in vision;
- Chest pain;
- Difficulty breathing or wheezing;
- Nausea or vomiting;
- Redness, blistering, peeling or loosening of the skin, including inside the mouth;
- Severe abdominal pain;
- Slurred speech or weakness on one side of the body;
- Unexplained weight gain or swelling;
- Unusual bleeding or bruising;
- Unusually weak or tired;
- Yellowing of eyes or skin;
- Diarrhea;
- Dizziness;
- Headache;
- Heartburn;
- Headache;
- Dizziness;
- Nervousness;
- Diarrhea;
- Constipation;


- Loss of consciousness;
- Fainting;
- Dizziness;
- Blurred vision;
- Upset stomach;
Without Prescription (2017)