Without a Prescription

Children taking sulfa drugs such as Sulfisoxazole should have frequent blood counts.
Sulfisoxazole is a children's medication prescribed for the treatment of severe, repeated, or long-lasting urinary tract infections.
Sulfisoxazole is prescribed in the treatment of bacterial infections such as trachoma and inclusion conjunctivitis (eye infections), nocardiosis (bacterial disease affecting the lungs, skin, and brain), and chancroid (venereal disease causing enlargement and ulceration of lymph nodes in the groin).
Malaria that does not respond to the drug chloroquine (Aralen) can be treated with Sulfisoxazole in combination with other drug treatment.
Notify your doctor at the first sign of a reaction such as skin rash, sore throat, fever, joint pain, cough, shortness of breath, or other breathing difficulties, abnormal skin paleness, reddish or purplish skin spots or yellowing of the skin or whites of the eyes.
Rare but severe reactions, sometimes fatal, have occurred with the use of sulfa drugs such as Sulfisoxazole. These reactions include sudden and severe liver damage, agranulocytosis (a severe blood disorder), and Stevens-Johnson syndrome (severe blistering).
Some middle ear infections are treated with Sulfisoxazole in combination with penicillin or erythromycin.
These include pyelonephritis (bacterial kidney inflammation), pyelitis (inflammation of the part of the kidney that drains urine into the ureter), and cystitis (inflammation of the bladder).
This drug is prescribed to treat bacterial meningitis, and is prescribed as a preventive measure for children who have been exposed to meningitis.
Toxoplasmosis (parasitic disease transmitted by infected cats, their feces or litter boxes, and by undercooked meat) can be treated with Sulfisoxazole in combination with pyrimethamine (Daraprim).

Side Effects

Sulfisoxazole side effects that you should report to your health care professional or doctor as soon as possible:

Side effects may include:
- Tongue and throat);
- Tarry stools;
- Skin rash);
- Skin eruptions;
- Shortness of breath;
- Severe skin welts or swelling;
- Serum sickness (fever;
- Sensitivity to light;
- Ringing in the ears;
- Retention of urine;
- Reddish or purplish skin spots;
- Rapid heartbeat;
- Presence of blood or crystals in urine;
- Palpitations;
- Painful joints;
- Nausea;
- Muscle pain;
- Low blood sugar;
- Lips;
- Lack or loss of appetite;
- Lack of muscle coordination;
- Lack of feeling or concern;
- Kidney failure;
- Joint pain;
- Itching;
- Inflammation of the mouth or tongue;
- Increased urination;
- Inability to urinate;
- Inability to fall or stay asleep;
- Hives;
- Hepatitis;
- Hearing loss;
- Headache;
- Hallucinations;
- Gas;
- Flushing;
- Fever;
- Fatigue;
- Fainting;
- Exhaustion;
- Enlarged thyroid;
- Enlarged salivary glands;
- Enlarged lymph nodes;
- Drowsiness;
- Dizziness;
- Disorientation;
- Diarrhea;
- Depression;
- Dark;
- Cough;
- Convulsions;
- Colitis;
- Chills;
- Bluish discoloration of the skin;
- Anxiety;
- Angioedema (swelling of face;
- Anemia and other blood disorders;
- Allergic reactions;
- Abdominal pain;
- Abdominal bleeding;


Sulfisoxazole is contraindicated if you have any of the following conditions:
- If your child develops a skin rash;
- If your child develops diarrhea;
- If your child has a kidney problem;
- If your child has impaired kidney or liver function, or severe allergies or bronchial asthma;
- If your child is sensitive to or has ever had an allergic reaction to Sulfisoxazole or other sulfa drugs;


Do not take Sulfisoxazole with any of the following drugs:
- Oral diabetes drugs such as micronase;
- Methotrexate, an anticancer drug;
- Blood-thinning drugs such as coumadin;



The usual dose for children 2 months of age or older is 150 milligrams per 2.2 pounds of body weight divided into 4 to 6 doses taken over 24 hours.
This medication should not be prescribed for infants under 2 months of age except in the treatment of congenital toxoplasmosis (a parasitic infection contracted by pregnant women and passed along to the fetus).

Doses should not exceed 6 grams over 24 hours.
The usual starting dose is one-half of the regular dose, or 75 milligrams per 2.2 pounds of body weight divided into 4 to 6 doses taken over 24 hours.

Sulfisoxazole pediatric suspension supplies a half-gram (500 milligrams) in each teaspoonful.


Symptoms of an overdose of Sulfisoxazole include:
- Yellowing of skin and whites of eyes;
- Vomiting;
- Unconsciousness;
- Nausea;
- Lack or loss of appetite;
- Headache;
- Fever;
- Drowsiness;
- Dizziness;
- Colic;
- Blue tinge to the skin;
- Blood or sediment in the urine;
Without Prescription (2017)