Sirolimus

 
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Without a Prescription

Sirolimus is prescribed to decrease the immune system's response to a transplanted organ.
Sirolimus is in a class of medications called immunosuppressants.
Sirolimus is prescribed in combination with other drugs to prevent rejection of kidney transplants.
Sirolimus works by suppressing the body's immune system.

Contraindications

Sirolimus is contraindicated if you have any of the following conditions:
- Heart disease;
- High cholesterol or triglycerides;
- Infection;
- Liver disease;
- An unusual or allergic reaction to Sirolimus, other drugs, foods, dyes, or preservatives;
- Pregnant or trying to get pregnant;
- Breast-feeding;
- Tell your doctor and pharmacist if you are allergic to Sirolimus or any other medications.
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: amphotericin B (Abelcet, AmBisome, Amphocin, Fungizone) antifungals such as clotrimazole (Lotrimin), fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral) bromocriptine (Parlodel) cimetidine (Tagamet) cisapride (Propulsid) clarithromycin (Biaxin) danazol (Danocrine) diltiazem (Cardizem, Dilacor, Tiazac) erythromycin (E.E.S., E-Mycin, Erythrocin) HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir) medications for seizures such as carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin) metoclopramide (Reglan) nicardipine (Cardene) rifabutin (Mycobutin) rifampin (Rifadin, Rimactane) rifapentine (Priftin) troleandomycin (TAO) and verapamil (Calan, Covera, Isoptin, Verelan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- If you are taking cyclosporine (Neoral) soft gelatin capsules or solution, take them 4 hours before Sirolimus.
- Tell your doctor what herbal products you are taking, especially St. John's wort.
- Tell your doctor if you have or have ever had high cholesterol or triglycerides or liver disease.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use an effective method of birth control before starting to take Sirolimus, while taking Sirolimus, and for 12 weeks after stopping Sirolimus. If you become pregnant while taking Sirolimus, call your doctor.
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Sirolimus.
- Plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Sirolimus may increase your risk for skin cancer.

Interactions

Do not take Sirolimus with any of the following drugs:
- Certain antibiotics like clarithromycin, erythromycin;
- Grapefruit juice;
- Drugs for fungal infections like itraconazole, ketoconazole, posaconazole, and voriconazole;
- Rifabutin, rifampin;
- Bromocriptine;
- Carbamazepine;
- Cimetidine;
- Cisapride;
- Clotrimazole;
- Cyclosporine;
- Danazol;
- Diltiazem;
- Fluconazole;
- Metoclopramide;
- Nicardipine;
- Phenobarbital;
- Phenytoin;
- Rifapentine;
- Some drugs for HIV;
- St John's wort;
- Vaccines;
- Verapamil;

Side Effects

Sirolimus side effects that you should report to your health care professional or doctor as soon as possible:
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Breathing problems;
- Chills, fever, sore throat;
- Dark urine;
- Fast, irregular heart beat;
- Feeling faint or lightheaded, falls;
- High blood pressure;
- Pinpoint red spots on the skin;
- Swelling, water retention;
- Trouble passing urine or change in the amount of urine;
- Unusual bleeding or bruising;
- Unusually weak or tired;
- Aches, pain;
- Acne;
- Diarrhea;
- Nausea, vomiting;
- Stomach upset;
- Tremor;
- Trouble sleeping;
- Stomach pain;
- Weakness;
- Back pain;
- Headache;
- Constipation;
- Diarrhea;
- Upset stomach;
- Vomiting;
- Swelling of the hands feet ankles or lower legs;
- Weight gain;
- Joint pain;
- Difficulty falling asleep or staying asleep;
- Tremor;
- Rash;
Without Prescription (2017)