Without a Prescription
Simvastatin can be prescribed to reduce the risk of coronary heart disease in people who have already had a heart attack, or who suffer from angina or diabetes. In these people Zocor slows down hardening of the arteries, regardless of your cholesterol level. It reduces the risk of needing procedures to improve blood supply to the heart, such as a balloon dilation of an artery or a heart bypass graft. It reduces the risk of heart attack and death.
Simvastatin causes a small decrease in the production of other 'bad fats' in the blood called triglycerides, and a small increase in the level of HDL cholesterol. This results in lowered levels of 'bad fats' and raised levels of 'good fats' in the blood.
Simvastatin decreases the production of LDL cholesterol by blocking the action of the enzyme in the liver that is responsible for its production. This decreases the amount of cholesterol in the liver cells, which causes them to take up LDL cholesterol from the blood. The decreased cholesterol production and increased removal of LDL cholesterol from the blood ultimately results in lowered blood cholesterol levels.
Simvastatin is a cholesterol-lowering drug. Your doctor may prescribe Simvastatin in addition to a cholesterol-lowering diet if your blood cholesterol level is too high, and if you have been unable to lower it by diet alone. For people at high risk of heart disease, current guidelines call for considering drug therapy when LDL levels reach 130. For people at lower risk, the cut-off is 160. For those at little or no risk, it's 190.
Simvastatin is prescribed to lower cholesterol in people who have high levels either due to genetics or as a result of diet and lifestyle. This helps to reduce the risk of atherosclerosis, angina and heart attacks.
Simvastatin tablets contain the active ingredient Simvastatin, which is a type of drug called a statin. Zocor is available without a brand name, ie as the generic drug. Zocor works by reducing the production of cholesterol by the liver.
As the body produces most cholesterol at night, statins are generally more effective if taken at night.
For the sake of simplicity, there are two sorts of cholesterol a 'bad' sort called low density lipoprotein and a 'good' sort called high density lipoprotein. LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries, while HDL actually protects the arteries against this.
In people with high cholesterol and heart disease, Simvastatin reduces the risk of heart attack, stroke, and "mini-stroke" (transient ischemic attack) and can stave off the need for bypass surgery or angioplasty to clear clogged arteries. Simvastatin can reduce these risks in people with diabetes, peripheral vascular disease, and a history of stroke.
It is important to continue to follow a cholesterol-lowering diet and exercise regime while taking Zocor. Discuss this with your doctor.
Statins have an important role in the prevention of coronary heart disease. They reduce the risk of excess cholesterol being deposited in the major blood vessels of the heart. Any blockage in the blood vessels limits the amount of blood and therefore oxygen being carried to the heart muscle. This can cause chest pain and in severe cases can result in a heart attack.
Simvastatin is prescribed for the treatment of:
- High blood cholesterol levels;
- High levels of any or all of the fats in the blood, such as cholesterol, triglycerides and lipoproteins;
- Inherited high blood cholesterol levels;
- Reducing risk of death and illness from coronary heart disease in people who have had a heart attack, or who have angina or diabetes;
Simvastatin side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Feeling of weakness;
- Hair loss;
- Liver disorders;
- Muscle disorders;
- Nausea and vomiting;
- Pins and needles;
- Rash or itching;
You will have to follow a standard cholesterol-lowering diet before starting treatment with Simvastatin and continue this diet while using Simvastatin.
All doses should be adjusted to your individual needs.
CHILDREN 10 TO 17 YEARS OLD
The safety and effectiveness of Simvastatin in children under 10 years old or in doses greater than 40 mg a day have not been studied.
The recommended starting dose is 10 mg once a day in the evening. The dosage may be increased every 4 weeks, as determined by the doctor, up to a maximum of 40 mg a day. Girls must have been menstruating for at least 1 year before starting therapy with Simvastatin.
Those who have severe kidney disease should use Simvastatin with caution. The recommended starting dose is 5 mg per day.
The usual starting dose is 20 to 40 mg once a day in the evening. If your cholesterol level or heart attack risk is especially high, the doctor may start with a dose of 40 mg. The dosage can be adjusted every 4 weeks. Some people with severe, hereditary high cholesterol may be prescribed as much as 80 mg a day, taken in doses of 20, 20, and 40 mg, along with other treatments.
When combined with cyclosporine, niacin, Atromid-S, Lopid, or Tricor, the dosage of Simvastatin should not exceed 10 mg a day. When combined with Calan or Cordarone, the dosage of Simvastatin should not exceed 20 mg a day.