Without a Script
Infrequently, serious (sometimes fatal) liver disease has occurred with the use of these two drugs alone.
Pyrazinamide is prescribed in combination with other anti-tuberculosis medications. Use of only rifampin and Pyrazinamide as a two-drug, two-month therapy to treat tuberculosis (specifically "latent" TB infection) is no longer recommended.
Pyrazinamide is prescribed in the treatment of tuberculosis.
Pyrazinamide is prescribed to patients who are suffering from tuberculosis.
Several other effective alternative treatments can be prescribed to treat latent tuberculosis (e.g., isoniazid for 9 months).
Use of rifampin and Pyrazinamide as part of a multi-drug (3 or more drugs) treatment plan for tuberculosis is still acceptable.
Pyrazinamide is contraindicated if you have any of the following conditions:
- Diabetes mellitus;
- Kidney disorder;
- Liver disorder;
Do not take Pyrazinamide with any of the following drugs:
- Zyloprim (allopurinol);
Pyrazinamide side effects that you should report to your health care professional or doctor as soon as possible:
- A fever;
- A rash;
- Abnormal / unusual fatigue and / or weakness;
- An allergic reaction to this medicine's components (closing of the throat difficulty breathing swelling of your tongue, lips, or face some patients develop hives);
- Dark urine;
- Painful or difficult urination;
- Swollen or painful joints;
- Vomiting, nausea, or loss of appetite;
- Worsening gout;
- Yellow eyes or skin (jaundice);
Stomach upset, muscle aches or acne may occur the first several days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor.
Tell your doctor immediately if any of these unlikely but serious side effects occur:
- Dark urine;
- Pain or swelling of the joints;
- Stomach pain;
- Yellowing eyes or skin;
Other Brand Names
In some countries Pyrazinamide may also be known as:
- Rifacom E-Z;