Probenecid

 
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Without a Script

Lowering uric acid levels may also help your kidneys. Probenecid is sometimes used along with penicillin antibiotics (penicillin, ampicillin, nafcillin) to increase antibiotic blood levels.
Probenecid belongs to a class of drugs known as uricosurics.
Probenecid is prescribed for the treatment of gout and high levels of uric acid in the blood.
Probenecid is prescribed to prevent gout and gouty arthritis.
Probenecid lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid.
Probenecid should not be used in children younger than 2 years.
Probenecid will not treat a sudden/severe attack of gout and may make it worse.
Probenecid works by decreasing the kidneys' ability to remove the antibiotic from the body.
This increase makes the antibiotic work better at treating certain infections.
When uric acid levels get too high, crystals can form in the joints, causing gout.

Contraindications

Probenecid is contraindicated if you have any of the following conditions:
- if you are allergic to probenecid;
- if you have a certain enzyme deficiency (G6PD);
- if you have any other allergies;
- if you have cancer treatment;
- if you have certain medical conditions;
- if you have certain type of kidney stone (uric acid);
- if you have kidney problems (kidney stones, obstruction);
- if you have low blood counts (aplastic anemia, bone marrow depression);
- if you have peptic ulcer disease;

Interactions

Do not take Probenecid with any of the following drugs:

Methotrexate Probenecid increases the effect and toxicity of methotrexate:
- Aspirin;

Probenecid increases the effect and toxicity of ganciclovir/valganciclovir:
- Ganciclovir;
- Valganciclovir;

The salicylate decreases the uricosuric effect of probenecid:
- Bismuth Subsalicylate;
- Salicylate-magnesium;
- Salicylate-sodium;
- Salsalate;
- Trisalicylate-choline;
- Zidovudine;

Probenecid increases the antibiotic's level:
- Moxalactam;
- Loracarbef;
- Cephalothin;
- Cephaloglycin;
- Cephalexin;
- Cefuroxime;
- Ceftizoxime;
- Cefradine;
- Cefprozil;
- Cefoxitin;
- Cefotetan;
- Cefotaxime;
- Cefonicid;
- Cefmetazole;
- Cefixime;
- Cefepime;
- Cefazolin;
- Cefamandole;
- Cefadroxil;
- Cefaclor;

Side Effects

Probenecid side effects that you should report to your health care professional or doctor as soon as possible:
- Cancer chemotherapy;
- Certain "water pills";
- Certain antibiotics such as cephalosporins/penicillins/beta lactams/nitrofurantoin;
- Certain drugs removed from your body by the kidneys;
- Change in amount/color of urine;
- Dapsone;
- Dark urine;
- Difficult/painful urination;
- Dizziness;
- Doripenem;
- Dyphylline;
- Easy bruising/bleeding;
- Fever;
- Frequent urination;
- Furosemide;
- Ganciclovir;
- Headache;
- Heparin;
- Ibuprofen;
- Indomethacin;
- Itching/swelling (especially of the face/tongue/throat);
- Ketorolac;
- Loss of appetite;
- Lower back pain;
- Methotrexate;
- Naproxen;
- Nausea;
- NSAIDs;
- Pale stools;
- Pyrazinamide;
- Rash;
- Salicylates (high-dose aspirin);
- Severe abdominal pain;
- Severe dizziness;
- Signs of infection;
- Sore gums;
- Sore throat;
- Sulfonylurea medicine to treat diabetes such as chlorpropamide;
- Thiazide diuretics;
- Trouble breathing;
- Unusual tiredness;
- Vomiting;
- Yellowing eyes/skin;
- Zidovudine;

Overdose

Reported Probenecid overdose symptoms are:
- Loss of consciousness;
- Severe vomiting;
- Seizures;

Other Brand Names

In some countries Probenecid may also be known as:
- Uricosid;
- Tubophan;
- Synergid R;
- Prolongine;
- Probexin;
- Probenemid;
- Probenecid Acid;
- Proben-C;
- Proben;
- Probecid;
- Probampacin;
- Probalan;
- Polycillin-PRB;
- Col-Probenecid;
- Colbenemid;
- Benuryl;
- Benemid;
- Benecid;
- Apurina;
Without Prescription (2017)