Each single dose vial contains 4.5 g of piperacillin sodium Ė tazobactam sodium Piperacillin sodium BP equivalent to 4 gms of piperacillin Tazobactam sodium BP equivalent to 0.5 g of tazobactam as sterile freeze dried powder for reconstitution
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Piperacillin has been shown to be active against most strains of b-lactamase producing micro-organisms both in vitro and in clinical infections.
Indicated for the treatment of moderate to severe infections.
Appendicitis (complicated by rupture or abscess) and peritonitis: the Bacteroides group: B. fragilis etc.
Complicated skin and skin structure infections: Including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections.
Postpartum endometritis or pelvic inflammatory disease.
Community-acquired pneumonia (moderate severity only)
Nosocomial pneumonia (moderate to severe)
Nosocomial pneumonia: Start with 4.5 g every 8 hours plus an aminoglycoside. The recommended duration of treatment is 7 to 14 days. Continue the aminoglycoside in patients from whom P.aeruginosa is isolated.
Renal function impairment: Patients with renal insufficiency adjust the IV dose to the degree of actual renal function impairment.
Haemodialysis: The maximum dose is 2.25 g every 8 hours. In addition, because haemodialysis removes 30% to 40% of a dose in 4 hours, one additional 0.75 g dose is recommended following each dialysis period. No dosage replacement required in peritoneal dialysis
Duration of therapy: The recommended duration of Piperacillin treatment of nosocomial pneumonia is 7 to 14 days. In all conditions, the duration of therapy should be guided by severity of infection and the patientís clinical and bacteriological progress.
Intravenous administration: For conventional vials, reconstitute Piperacillin per 1 gram of piperacillin with 5 ml of a compatible reconstitution diluent (given below) Shake well until dissolved.
Compatible reconstituted diluents: These include 0.9% sodium chloride for injection, sterile water for injection, dextrose 5%, bacteriostatic saline/Parabens, bacteriostatic water/Benzyl alcohol. Lactated Ringerís solution is not compatible. Dilute to at least 50 ml to 150 ml. Administer over a period of at least 30 minutes.
Piperacillin is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or b-lactamase inhibitors.
- Injection 4.5 g;