Without a Prescription

Pemetrexed affects cells that are rapidly growing, such as cancer cells and cells in your mouth and stomach.
Pemetrexed is a chemotherapy drug.
Pemetrexed is prescribed to treat lung cancers like non-small cell lung cancer and mesothelioma.
Pemetrexed is prescribed to treat other cancers.


Pemetrexed is contraindicated if you have any of the following conditions:
- If you have an unusual or allergic reaction to pemetrexed, mannitol, other medicines, foods, dyes, or preservatives;
- If you have breast-feeding;
- If you have if you frequently drink alcohol containing beverages;
- If you have infection (especially a virus infection such as chickenpox, cold sores, or herpes);
- If you have kidney disease;
- If you have liver disease;
- If you have low blood counts, like low platelets, red bloods, or white blood cells;
- If you have pregnant or trying to get pregnant;


Do not take Pemetrexed with any of the following drugs:
- Acetaminophen;
- Aspirin;
- Aspirin and aspirin-like medicines;
- Ibuprofen;
- Ketoprofen;
- Medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim;
- Methotrexate;
- Naproxen;
- Nsaids, medicines for pain and inflammation, like ibuprofen or naproxen;
- Probenecid;
- Pyrimethamine;
- Vaccines;


Pemetrexed may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu.
Call your doctor or health care professional if you get diarrhea or mouth sores. Do not treat yourself.
Do not become pregnant while taking this medicine. Tell your doctor right away if you think that you or your partner might be pregnant.
Do not breast-feed an infant while taking Pemetrexed. This medicine may lower sperm counts.
Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
If you have any dental work done, tell your dentist you are receiving Pemetrexed.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Men and women must use effective birth control while taking this medicine.
Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.
This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells.
To protect your kidneys, drink water or other fluids as directed while you are taking this medicine.
Visit your doctor for checks on your progress. Pemetrexed may make you feel generally unwell.
You may also need to continue using effective birth control for a time after stopping Pemetrexed.

Side Effects

Pemetrexed side effects that you should report to your health care professional or doctor as soon as possible:
- Yellowing of the eyes or skin;
- Vomiting;
- Trouble passing urine or change in the amount of urine;
- Swelling of the ankles, feet, hands;
- Stomach upset;
- Signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine;
- Signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness;
- Signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine;
- Pain, swelling, warmth in the leg;
- Pain on swallowing;
- Nausea;
- Mouth or throat sores or ulcers;
- Low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. you may be at increased risk for infections and bleeding;
- Loss of appetite;
- High blood pressure;
- Hair loss;
- Diarrhea;
- Confusion;
- Chest pain;
- Changes in emotions or moods;
- Breathing problems, like a dry cough;
- Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
Without Prescription (2017)