Ofloxacin

 
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Structure

Oflox Eye/Ear Drops
Ofloxacin USP 0.3% w/v Benzalkonium Chloride NF 0.01% w/v (as preservative) Sterile aqueous vehicle q.s.

Oflox Eye Ointment
Ofloxacin USP 0.3% w/w, Benzalkonium Chloride NF 0.01% w/w

Oflox-100 Tablets
Each film-coated tablet contains Ofloxacin USP 100

Oflox-200 Tablets
Each film-coated tablet contains Ofloxacin USP 200

Oflox-400 Tablets
Each film-coated tablet contains Ofloxacin USP 400

Oflox I.V. Infusion
Each 100 ml contains Ofloxacin USP 200 , Sodium Chloride IP 0.9% w/v, Water for injection IP q.s. to 100 ml

Oflox-TZ Tablets
Each film-coated tablet contains Ofloxacin USP 200 Tinidazole IP 600 mg

Without a Prescription

Ofloxacin Eye Drops are prescribed in the topical treatment of a variety of external infections of the eye and its adnexa caused by susceptible bacteria including Chlamydia trachomatis.
Such infections: acute and sub-acute conjunctivitis, mucopurulent conjunctivitis, blepharo-conjunctivitis, blepharitis, bacterial corneal ulcer with or without hypopyon, bacterial keratitis and kerato-conjunctivitis, chronic dacryocystitis, meibomianitis, pre-operative prophylaxis in ocular surgery, treatment of post-operative infections, external ocular infections following foreign body or injury and in ocular infections not responding to other topical treatments.
Ofloxacin Ear Drops are prescribed in the topical treatment of ear infections like otitis externa in adults and children, chronic suppurative otitis media with perforated tympanic membranes in adults and acute otitis media in the presence of tympanostomy tubes in children.
Ofloxacin Eye Ointment is prescribed in the topical treatment of a variety of external infections of the eye and its adnexa caused by susceptible bacteria including Chlamydia trachomatis, especially infections like acute and sub-acute conjunctivitis, mucopurulent conjunctivitis, blepharo-conjunctivitis, blepharitis, bacterial corneal ulcer with or without hypopyon, bacterial keratitis and kerato-conjunctivitis, chronic dacryocystitis, meibomianitis, pre-operative prophylaxis in ocular surgery, treatment of post-operative infections, external ocular infections following foreign body or injury and in ocular infections not responding to other topical treatments.

Ofloxacin-TZ is prescribed for the treatment of a wide variety of infections caused by susceptible gram-positive and gram-negative organisms along with anaerobes and protozoa.

Surgical prophylaxis and surgical wound infections.
Gynaecological infections including prophylaxis in gynaecological surgeries.
Respiratory tract infections like lung abscess, aspiration pneumonia, empyema and bronchiectasis.
ENT infections like chronic sinusitis, chronic suppurative otitis media, cholesteatoma and mastoiditis.
Orofacial and dental infections.
Dermatological infections like cellulitis, breast and other cutaneous abscesses, gangrene, diabetic and decubitus ulcers.
Intra-abdominal infections and diarrhoeas of mixed bacterial and protozoal origin.

Ofloxacin is prescribed for the treatment of the following bacterial infections if these are due to Ofloxacin-sensitive pathogens.
Acute, chronic or recurrent respiratory tract infections (bronchitis): caused by Haemophilus influenzae or other gram-negative or multi-drug resistant pathogens, as well as Staphylococcus aureus.
Pneumonias, especially if caused by pathogens such as Escherichia coli, Enterobacter, Proteus, Pseudomonas, Legionella or Staphylococcus.
Chronic and recurrent infections of ear, nose and throat especially if caused by gram-negative pathogens including Pseudomonas or by Staphylococcus (not recommended for treatment of acute tonsillitis).

Skin and skin structure infections
Infections of the abdominal cavity (e.g. bacterial infections of gastrointestinal tract, the biliary duct, peritonitis).

Infections of the kidneys, urinary tract and genital organs, gonorrhoea.
MDR-TB (Multi-drug resistant tuberculosis)

Dosage

In ocular infections
In mild to moderate infections:
Instil one or two drops into the affected eye(s) every 4 hours.
In severe infections:
Instil 2 drops into the eye(s) hourly until improvement is obtained following which treatment should be reduced.
In ear infections
For otitis externa
In adults 10 drops twice daily and in children (1-12 yrs.) 5 drops twice daily
For chronic suppurative otitis media with perforated tympanic membranes
In adults 10 drops twice daily for 14 days.
For acute otitis media in the presence of tympanostomy tubes in children
5 drops twice daily for 14 days.
The otic drops should be instilled into the ear canal of the infected ear, while the patient lies with the ear upwards.
The position should be maintained for at least 5 minutes after administration.

In mild to moderate ocular infections:
Apply thin strip (about 1 cm) of ointment into the affected eye(s) every 4 hours.
In severe ocular infections:
Apply thin strip (about 1 cm) of ointment into the eye(s) hourly until improvement is obtained following which treatment should be reduced.

The dose of Ofloxacin is determined by the type and severity of the infection.
The dosage range for adults is 200 to 800 mg daily. Up to 400 mg as a
single dose should be given in the morning. Larger doses should be given
as two divided doses.

Dosage in patients with impaired liver function: The excretion of Oflox may be reduced in patients with severe impairment of liver function (e.g. cirrhosis with ascites).
A maximum daily dose of 400 Ofloxacin should therefore not be exceeded.
MDR-TB: Ofloxacin 400 twice daily with first-line anti-TB drugs for 6-9 months.
Elderly
No adjustment of dosage is required in the elderly other than that imposed by consideration of renal function.

The usual adult dose is one tablet of Ofloxacin-TZ twice a day.
The doses may be increased in severe infections.
The duration of treatment depends upon the type and severity of infection.

Contraindications

Ofloxacin is contraindicated if you have any of the following conditions:
- Hypersensitivity to the quinolone group or the nitroimidazole group of compounds and in those patients with a history of blood dyscrasias;
- Ofloxacin is contraindicated in epileptics;
- Ofloxacin must not be used in patients with pre-existing central nervous system lesions involving a lowered convulsion threshold, e.g. after cerebrocranial injuries, inflammation in the region of the central nervous system or stroke;
- Ofloxacin should not be used in patients hypersensitive to Ofloxacin or any other quinolone;

Package

- Blister pack of 10 tablets;
- FFS vial of 100 ml;
- 5 ml vial;
- 5 gm tube;
Without Prescription (2017)