Without a Prescription

A remedy for the symptoms of menopause, CombiPatch combines the hormones estrogen (estradiol) and progestin (norethindrone acetate) in a slow-release patch that's applied to the skin.
CombiPatch can be prescribed as an estrogen supplement by women unable to produce sufficient amounts of estrogen on their own.
Hormone replacement therapy employing estrogen alone has been linked to a dramatic increase in the risk of endometrial cancer (cancer in the lining of the uterus).
However, addition of a progestin to the treatment, as in CombiPatch, reverses this increase.
It is prescribed to relieve external vaginal irritation and internal vaginal dryness.
Problems prompting the need for supplementation include ovarian failure, hypogonadism (impaired hormone production), and surgical removal of the ovaries.
The product eases such symptoms of menopause as feelings of warmth in the face, neck, and chest, and the sudden intense episodes of heat and sweating known as "hot flashes."
While critics of hormone replacement therapy are concerned about its cancer-causing potential, proponents point out that, in addition to relieving menopausal symptoms, hormone replacement appears to have a protective effect against heart disease and brittle bones (osteoporosis).

Side Effects

Norethindrone-Acetate side effects that you should report to your health care professional or doctor as soon as possible:

More common side effects may include:
- Weakness;
- Vaginal inflammation;
- Vaginal bleeding or discharge;
- Tooth disorders;
- Swelling;
- Sore throat;
- Skin reaction;
- Sinus inflammation;
- Runny nose;
- Respiratory problems;
- Rash;
- Painful or increased menstruation;
- Pain;
- Nervousness;
- Nausea;
- Menstrual problems;
- Joint pain;
- Insomnia;
- Infection;
- Indigestion;
- Headache;
- Gas;
- Flu symptoms;
- Dizziness;
- Diarrhea;
- Depression;
- Constipation;
- Bronchitis;
- Breast enlargement or pain;
- Back pain;
- Acne;
- Abnormal PAP smear results;
- Abdominal pain;


Norethindrone-Acetate is contraindicated if you have any of the following conditions:
- If you have a blood pressure problem;
- If you have a condition that could be aggravated by excess fluid such as asthma, epilepsy, migraine headaches, heart disease, or kidney problems use combipatch with caution;
- If you have a history of deep vein thrombosis (a clot in the legs), or of thrombosis in your family;
- If you have an allergy to any component of the patch;
- If you have any type of tumor stimulated by estrogen;
- If you have diabetes;
- If you have known or suspected breast cancer;
- If you have phlebitis, stroke, or any other clotting disorder;
- If you have unexplained vaginal bleeding;
- If you suffer a loss of vision, any other eye problems, or a migraine headache;


Do not take Norethindrone-Acetate with any of the following drugs:
The manufacturer has not reported interactions.



Your doctor may increase your dose to a patch containing 0.05 milligrams estradiol and 0.25 milligrams norethindrone acetate if needed.
The recommended starting dose is one patch containing 0.05 milligrams estradiol and 0.14 milligrams norethindrone acetate applied twice a week (every 3 to 4 days).
The estradiol-only patch is applied twice a week for the first 14 days of a 28-day cycle, and CombiPatch is applied twice weekly for the remaining 14 days.
CombiPatch can be prescribed in conjunction with a 0.05 milligram estradiol-only patch such as the product brand-named Vivelle.

Irregular bleeding may occur, particularly in the first 6 months of therapy, but generally decreases with time and often stops completely.

If you are currently taking another form of hormone replacement therapy, you should complete the current cycle before switching to CombiPatch.


Even a large overdose of the hormones in CombiPatch would pose little danger; and the patch form of delivery renders such a dose highly unlikely.
Nevertheless, if you think there's a chance, seek medical attention immediately.
Symptoms would include nausea and withdrawal bleeding.
Without Prescription (2017)