Without a Prescription
Nolvadex D tablets contain the active ingredient Nolvadex citrate, which is a type of drug known as an 'anti-oestrogen'. Nolvadex is available without a brand name, ie as the generic drug. Nolvadex is mainly prescribed to treat women with breast cancers that respond to the female sex hormone, oestrogen.
Nolvadex helps prevent breast cancer from spreading to other areas of the body and reduces risk of developing cancer in the other breast.
Nolvadex is prescribed in the treatment of female infertility that is caused by problems with ovulation. Again, it acts by blocking oestrogen receptors, this time in a part of the brain called the hypothalamus. The effect of this is an increase in the levels of the hormones that control the development and release of an egg. These hormones are released from the pituitary gland and are known as follicle stimulating hormone and luteinising hormone. FSH stimulates the ovaries and LH causes the release of an egg from the ovaries.
Nolvadex is prescribed to reduce the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. Nolvadex can be prescribed to reduce the odds of breast cancer in women at high risk of developing the disease. It does not completely eliminate your chances, but in a five-year study of over 1,500 high-risk women, it slashed the number of cases by 44 percent.
Nolvadex works by blocking the oestrogen receptors, thereby blocking the effect of oestrogen on the cancer. This starves the breast cancer cells and stops them from growing.
Nolvadex, an anticancer drug, is given to treat breast cancer. It has proved effective when cancer has spread to other parts of the body. Nolvadex is most effective in stopping the kind of breast cancer that thrives on estrogen.
In the normal menstrual cycle, oestrogen acts on receptors in the hypothalamus after ovulation. This causes the pituitary gland to stop releasing FSH and LH. As Nolvadex blocks the oestrogen receptors in the hypothalamus, it prevents this action of oestrogen. FSH and LH levels therefore increase, which increases the chances of egg development and ovulation.
Most breast cancers are sensitive to oestrogen, and their growth is increased in the presence of this hormone. Oestrogen binds to oestrogen receptors on the breast cancer cells and causes changes within the cells that result in faster growth of the cancer. Breast cancers that are sensitive to oestrogen are called oestrogen receptor positive cancers.
Nolvadex is prescribed for the treatment of:
- Infertility in women caused by failure of ovulation;
- Breast cancer;
Nolvadex side effects that you should report to your health care professional or doctor as soon as possible:
- Blood disorders;
- Cancerous changes in the endometrium;
- Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain;
- Fibroids in the womb;
- Fluid retention;
- Hair loss;
- Hot flushes;
- Increased risk of abnormal blood clots within the blood vessels;
- Itching of the external female genitalia;
- Liver disorders;
- Severe blistering skin reaction affecting the tissues of the eyes, mouth, throat and genitals;
- Severe swelling of lips, face or tongue;
- Stimulation of tumour growth;
- Suppression of menstrual periods in pre-menopausal women receiving nolvadex for breast cancer;
- The presence of tissue similar to the lining of the uterus at other sites in the pelvis;
- Vaginal bleeding or discharge;
- Visual disturbances;
- Hot flashes;
Safety and efficacy in children have not been established.
Ductal Carcinoma in Situ
The recommended dose is 20 mg once daily for 5 years.
Breast Cancer Treatment
If you are taking more than 20 mg a day, your doctor will have you divide the total into 2 smaller doses taken in the morning and evening. Nolvadex comes in 10- and 20-mg tablets.
The daily dosage ranges from 20 to 40 mg.
Breast Cancer Prevention
The recommended dose is 20 mg once a day for up to 5 years.