Without a Prescription
Nizoral kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.
Nizoral tablets contain the active ingredient ketoconazole, which is a type of drug called an antifungal. It is prescribed to treat infections with fungi and yeasts.
Nizoral, a broad-spectrum antifungal drug available in tablet form, may be given to treat several fungal infections within the body, including oral thrush and candidiasis.
It may be given to treat severe, hard-to-treat fungal skin infections that have not cleared up after treatment with creams or ointments, or the oral drug griseofulvin (Fulvicin, Grisactin).
The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As ketoconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.
When taken by mouth Nizoral may very rarely cause serious side effects on the liver. As a result, Nizoral tablets are reserved for treating fungal infections that can't be treated with other antifungals.
Nizoral is prescribed for the treatment of:
Nizoral tablets are prescribed to treat fungal infections of the skin, hair or mucous membranes that can't be treated with topical ketoconazole due to the site or extent of the infection, and cannot be treated with other antifungals. These infections include the following:
- Candida infections of the skin, mucous membranes, mouth or throat;
- Chronic, recurrent vaginal thrush;
- Pityrosporum folliculitis;
Nizoral tablets are prescribed to treat fungal infections affecting the whole body that cannot be treated with other antifungals, including the following:
Nizoral side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Abnormal enlargement of breasts in men - very rare;
- Decreased numbers of blood cells called platelets in the blood - very rare;
- Erectile dysfunction - very rare;
- Hair loss - very rare;
- Menstrual disorders - very rare;
- Nausea and vomiting;
- Raised pressure inside the skull - very rare;
- Serious liver damage that may be fatal - very rare;
- Severe swelling of lips, face or tongue - very rare;
- Underactivity of the adrenal glands - very rare;
Nizoral has not been studied in children under 2 years of age.
In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg per 2.2 pounds of body weight has been used.
In very serious infections, or if the problem does not clear up within the expected time, the dose of Nizoral may be increased to 400 mg (2 tablets) once daily.
The recommended starting dose of Nizoral is a single daily dose of 200 mg (1 tablet).
Treatment lasts at least 1 to 2 weeks, and for some infections much longer.