Without a Prescription

Arrhythmias are often caused by drugs or disease but can occur in otherwise healthy people with no history of heart disease or other illness.
Irregular heart rhythms are generally divided into two main types: heartbeats that are faster than normal (tachycardia) and heartbeats that are slower than normal (bradycardia).
Mexiletine is prescribed in the treatment of patients who are suffering from severe irregular heartbeat.
Mexiletine is prescribed to treat severe irregular heartbeat (arrhythmia).
Mexiletine is known to affect the way in which the patient's heart beats.

Side Effects

Mexiletine side effects that you should report to your health care professional or doctor as soon as possible:
- A worsening or a new irregular heartbeat pattern;
- Abdominal pain/cramps;
- An allergic reaction (throat closing; difficulty breathing; swelling of your lips, face or tongue; hives);
- Angina (crushing chest pain);
- Appetite changes;
- Behavior changes;
- Bleeding from the stomach;
- Blurred vision;
- Changes in sleep habits;
- Chest pain;
- Confusion;
- Congestive heart failure;
- Constipation;
- Decreased sex drive;
- Depression;
- Depression;
- Depression;
- Diarrhea or constipation;
- Diarrhea;
- Difficult or labored breathing;
- Difficulty swallowing;
- Difficulty urinating;
- Dizziness, tiredness, lightheadedness;
- Dizziness;
- Dry mouth;
- Dry mouth;
- Dry skin;
- Excessive perspiration;
- Fainting;
- Fatigue;
- Fever, sore mouth, sore throat, mouth ulcers, or infections;
- Fever;
- Hair loss;
- Hallucinations;
- Headache or blurred vision;
- Headache;
- Heartburn;
- Hepatitis;
- Hiccups;
- High blood pressure;
- Hot flashes;
- Impotence;
- Joint pain;
- Light-headedness;
- Loss of consciousness;
- Low blood pressure;
- Nausea;
- Nervousness;
- Numbness, tremor or tingling;
- Numbness;
- Peptic ulcer;
- Poor coordination;
- Rash;
- Rash;
- Ringing in the ears;
- Ringing in your ears;
- Seizures;
- Short-term memory loss;
- Skin inflammation and flaking;
- Skin peeling;
- Slow heartbeat;
- Sore throat;
- Speech difficulties;
- Swelling due to fluid retention;
- Taste changes;
- Throbbing heartbeat;
- Tingling or pins and needles;
- Tremors;
- Unusual bleeding or bruising;
- Upset stomach, vomiting, heartburn, or decreased appetite;
- Upset stomach;
- Vision changes;
- Vomiting;
- Weakness;
- Wheezing, chest pain, coughing, or chest discomfort;


Mexiletine is contraindicated if you have any of the following conditions:
- Any type of heart problem or heart disease;
- Epilepsy;
- Liver disease;
- If you have a seizure disorder;
- If you have heart block;
- If you have heart failure, a heartbeat irregularity called heart block that has not been corrected by a pacemaker, structural heart disease;
- If you have liver disease or abnormal liver function as a result of congestive heart failure;
- If you have recently had a heart attack;


Do not take Mexiletine with any of the following drugs:
- Theophylline products such as theo-dur;
- Rifampin (rifadin);
- Phenytoin (dilantin);
- Phenobarbital;
- Other antiarrhythmic drugs such as norpace and quinidex;
- Cimetidine (tagamet);
- Caffeine products such as no-doz;
- Antacids such as maalox;



The safety and efficacy of Mexiletine have not been established in children.


Your doctor may adjust the dose by 50 or 100 mg up or down every 2 to 3 days.
The usual starting dose is 200 mg every 8 hours when quick control of an irregular heartbeat is not necessary.

The dosage of Mexiletine will be adjusted to your individual needs on the basis of your response to the drug.

You should see the effects of Mexiletine within 30 minutes to 2 hours.
When fast relief is needed, your doctor may start you on 400 mg of Mexiletine, followed by 200 mg in 8 hours.

If you do not, your doctor may raise your dose to 400 mg every 8 hours.
Most people will do well on 200 to 300 mg taken every 8 hours with food or antacids.
You should not take more than 1,200 mg in a day.

In general, people with reduced kidney function are prescribed the usual doses of Mexiletine, but those with severe liver disease may require lower doses and will be monitored closely.

If you do well on a Mexiletine dose of 300 mg or less every 8 hours, your doctor may decide to divide the daily total into 2 doses taken every 12 hours.
Some people who handle Mexiletine well may be transferred to a 12-hour dosage schedule that will make it easier and more convenient to take Mexiletine.


Dosages will be adjusted according to the individual's needs.


Reported Mexiletine overdose symptoms are:
- Coma;
- Dizziness;
- Loss of consciousness;
- Low blood pressure;
- Nausea;
- Seizures;
- Slow heartbeat or other heart problems;
- Tingling or numbness;
- Tingling or pins and needles;
- Tiredness;
- Worsening irregular heartbeat;

Other Brand Names

- Mexiletine;
- Katen;
- Tumetil;
- Mexicord;
Without Prescription (2017)