Memantine

 
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Without a Prescription

Memantine is prescribed for the treatment of moderate to severe dementia of the Alzheimer's type.
Memantine is prescribed for treating moderate to severe Alzheimer's disease.
Both chemicals are associated with memory and learning.
Studies show that Memantine can help improve the mental state and daily functioning of some people with Alzheimer's disease.
While other Alzheimer's drugs work to prevent the breakdown of the brain chemical acetylcholine, Memantine works by targeting glutamate.

Dosage

ADULTS

The recommended dosage is 10mg twice a day. The pharmacist will start treatment at 5mg once a day for 7 days, and gradually increase the dose by 5mg every 7 days, up to a maximum total daily dose of 20mg.

Overdose

Reported Memantine overdose symptoms are:
- Abnormal crying;
- Anxiety;
- Confusion;
- Cystitis;
- Dizziness;
- Fever;
- Hallucinations;
- Headache;
- Hypertonia;
- Increased apetite;
- Increased libido;
- Leg pain;
- Loss of consciousness;
- Pain;
- Psychosis;
- Restlessness;
- Sleepiness;
- Stupor;
- Tiredness;
- Vomiting;

Side Effects

Memantine side effects that you should report to your health care professional or doctor as soon as possible:
- Vomiting;
- Sleepiness;
- Pain;
- High blood pressure;
- Headache;
- Hallucinations;
- Dizziness;
- Coughing;
- Constipation;
- Confusion;

Brand Names

Other synonyms:
- DMAA;
- Ebixa;
- Memantina [INN-Spanish];
- Memantine [INN];
- Memantine HCL;
- Memantine Hydrochloride;
- Memantinum [INN-Latin];

Contraindications

Memantine has not been formally studied in people with seizure disorders.
Memantine is not recommended for use in patients who have severe kidney impairment.
Be sure to tell the doctor about any major dietary changes, kidney problems such as renal acidosis, or urinary tract infections.
Certain conditions can alter the alkaline balance of the urine, which may cause a buildup of Memantine in the body.
Make sure the doctor knows about any history of seizures.

Memantine is contraindicated in patients with known hypersensitivity to Memantine or to any excipients prescribed in the formulation.

Memantine is contraindicated in people who have ever had an allergic reaction to Memantine.

Interactions

Do not take Memantine with any of the following drugs:
- Triamterene;
- Sodium bicarbonate (baking soda);
- Ranitidine;
- Quinidine;
- Nicotine;
- Ketamine;
- Hydrochlorothiazide;
- Glaucoma drugs such as acetazolamide and methazolamide;
- Cough suppressants that contain dextromethorphan (usually denoted as "dm");
- Cimetadine;
- Amantadine;

Possible increased levels of memantine:
- Sodium bicarbonate;
- Methazolamide;
- Dichlorphenamide;
- Acetazolamide;

Increased risk of CNS adverse effects with this association:
- Ketamine;
- Dextromethorphan;
- Amantadine;
Without Prescription (2017)