Maprotiline is contraindicated if you have any of the following conditions:
- an unusual or allergic reaction to maprotiline, other medicines, foods, dyes, or preservatives;
- bipolar disorder;
- blood disorders;
- breast-feeding;
- heart disease;
- liver disease;
- pregnant or trying to get pregnant;
- previous heart attack;
- seizures;
- suicidal thoughts or family history of suicide;
- if you are allergic to Maprotiline;
- if you are allergic to tricyclic antidepressants (nortriptyline);
- if you have a certain eye problem (glaucoma);
- if you have any other allergies;
- if you have bleeding problems;
- if you have breathing problems;
- if you have conditions that may increase your risk of seizures (other brain disease, alcohol/sedative withdrawal);
- if you have family history of suicide;
- if you have kidney problems;
- if you have liver problems;
- if you have overactive thyroid (hyperthyroidism);
- if you have personal or family history of mental/mood conditions (bipolar disorder, psychosis);
- if you have problems urinating (due to enlarged prostate);
- if you have recent heart attack;
- if you have seizures;

Without a Prescription

Maprotiline belongs to a class of medications called tetracyclic antidepressants.
Maprotiline helps to relieve anxiety associated with depression.
Maprotiline is prescribed to treat depression.
Maprotiline is prescribed to treat various types of depression and related anxiety.
Maprotiline may help improve mood and feelings of well-being.
Maprotiline works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain.


Reported Maprotiline overdose symptoms are:
- Extreme drowsiness;
- Fainting;
- Fast/irregular heartbeat;
- Hallucinations;
- Seizures;
- Slow/shallow breathing;


Do not take Maprotiline with any of the following drugs:
- barbiturates, like phenobarbital;
- cimetidine;
- cisapride;
- cocaine;
- droperidol;
- halofantrine;
- levomethadyl;
- maois like carbex, eldepryl, marplan, nardil, and parnate;
- medicines for anxiety or sleeping problems, such as diazepam or temazepam;
- medicines for colds and breathing difficulties;
- medicines for hay fever and other allergies;
- medicines for high blood pressure;
- medicines for mental depression;
- medicines for the thyroid;
- medicines to control heart rhythm;
- phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine;
- phenytoin;
- pimozide;
- sparfloxacin;
- st. john's wort;
- ziprasidone;
- albuterol;
- amphetamines;
- anticholinergic drugs;
- antidepressants;
- arbutamine;
- belladonna alkaloids;
- benztropine;
- bronchodilators/decongestants;
- central-acting drugs to treat high blood pressure;
- cimetidine;
- clonidine;
- drugs to treat irregular heart rate;
- epinephrine;
- fluconazole;
- guanabenz;
- guanadrel;
- isocarboxazid;
- levodopa;
- linezolid;
- mao inhibitors;
- methyldopa;
- methylphenidate;
- moclobemide;
- paroxetine/fluoxetine/fluvoxamine;
- phenelzine;
- phenylephrine;
- procarbazine;
- quinidine/propafenone/flecainide;
- rasagiline;
- reserpine;
- selegiline;
- sibutramine;
- stimulants;
- streets drugs including mdma/"ecstasy";
- terbinafine;
- thyroid supplements;
- tranylcypromine;

Side Effects

Maprotiline side effects that you should report to your health care professional or doctor as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- blurred vision;
- breathing problems;
- change in sex drive or performance;
- confusion or nervousness;
- constipation;
- fast or irregular heartbeat;
- feeling faint or lightheaded, falls;
- fever with increased sweating;
- hallucinations;
- headache;
- muscle stiffness, twitches, or problems with movement;
- pale skin;
- seizures;
- suicidal thoughts or other mood changes;
- swelling or tenderness of breasts or testicles;
- trouble passing urine or change in the amount of urine;
- trouble sleeping;
- unusually weak or tired;
- yellowing of the eyes or skin;
- agitation;
- anxiety;
- blurred vision;
- chew (sugarless) gum;
- confusion;
- constipation;
- dizziness;
- drink water;
- drowsiness;
- dry mouth;
- fainting;
- fast/irregular heartbeat;
- itching/swelling (especially of the face/tongue/throat);
- mental/mood changes;
- persistent heartburn;
- rash;
- seizures;
- severe dizziness;
- severe stomach/abdominal pain;
- shaking;
- suck on (sugarless) hard candy or ice chips;
- to relieve dry mouth;
- trouble breathing;
- trouble urinating;
- use a saliva substitute;
Without Prescription (2017)