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Lidocaine-Prilocaine is an anesthetic for the skin. It is a eutectic mixture of Lidocaine 2.5% and Prilocaine 2.5%, meaning this mixture is formed at the lowest temperature possible. The ratio of the mixture is 1:1 by weight. Lidocaine-Prilocaine is prescribed to lessen pain and discomforts especially during surgical procedure when there is cutting of skin for operation and such. Lidocaine-Prilocaine in other words is a local skin anesthetic.
Lidocaine-Prilocaine could be applied to normal unbroken skin, and on genital mucous membranes for superficial minor surgery for local anesthetic purposes.


Lidocaine-Prilocaine is not recommended for patients who have known or unknown allergic reactions to local anesthesia or to patients with sensitivity to Lidocaine and or Prilocaine.
Lidocaine-Prilocaine should never be prescribed for optical purposes.


Before application of the Lidocaine-Prilocaine, make sure that the area for application is cleaned first and removed free from dirt and oils. This is usually done with scrubbing the area with a washcloth with soap and warm water. The Lidocaine-Prilocaine should be applied to the area generously. The cream should be at least ? of an inch thick.
Extend the application of the cream of at least ? inch past the intended area. After application, preferably cover the area with a saran-wrap. A saran-wrap is a very thin transparent plastic sheet made from saran. It is ideal to cover the area for it to continually remain thick. Secure the edges of the saran-wrap with a medical tape to avoid leakage.
If you are using the Lidocaine-Prilocaine that is contained in the anesthetic disk, that is the Topical Adhesive System, it will require another procedure for application. Just follow the instructions on the package insert.

How Lidocaine-Prilocaine it Works

Application of the Lidocaine-Prilocaine on the skin with a dressing either with the saran-wrap or with the anesthetic disk or with any occlusive dressing, provides dermal analgesia. It numbs the epidermal and dermal layers of the skin. Its composition of Lidocaine and Prilocaine accumulated at the mentioned layers of the skin numbs the pain receptors and the nerve endings thus freezing the feeling of the skin.
The components of Lidocaine-Prilocaine are local anesthetic agents and work by stabilizing the neuronal membranes by the inhibition of ionic fluxes necessary to the conduction of nerve impulses therefore the anesthetic action.
The depth of the penetration of the drug is dependent upon the thickness of the cream applied and the duration with which the cream was applied to the skin. For general purposes, Lidocaine-Prilocaine should applied for at least one hour. For clinical procedures, Lidocaine-Prilocaine should be applied for two hours under occlusive dressing.

Side Effects

Dermal Application of Lidocaine-Prilocaine may cause a fleeting and temporary blanching and redness or erythema.
When a person is allergic to either Lidocaine or Prilocaine, the following symptoms might occur:
- Angioedema;
- Bronchospasm;
- Shock;
- Urticaria;

There are no known side effects or any adverse effects when Lidocaine-Prilocaine was tested in rats, however, no well-controlled studies were conducted in pregnant women.


Toxic Levels of Lidocaine and or Prilocaine may cause a decrease in cardiac performance, total peripheral resistance and arterial pressure. These effects may be attributed to the depressant actions of local anesthetic agents on the cardiovascular system.

Other Brand Names

In some countries Lidocaine-Prilocaine may also be known as:
- Citanest con Octapressin;
- Citanest Dental;
- Citanest Octapressin;
- Citanest;
- Citocaina;
- Octapressin;
- Prilocaine;
- Pristesin F;
- Xylonest;
Without Prescription (2017)