Indinavir

 
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Structure

Indinavir-400 Capsules
Each capsule contains Indinavir Sulphate equivalent to Indinavir 400 mg.

Dosage

The recommended dosage of indinavir is 800 mg (two 400 mg capsules) orally every 8 hours.
For optimal absorption, indinavir should be administered without food but with water 1 hour before or 2 hours after a meal.
To ensure adequate hydration, it is recommended that the patient drink at least 1.5 litres (approximately 48 ounces) of liquids during the course of 24 hours.

Hepatic Insufficiency
The dosage of Indinavir should be reduced to 600 mg every 8 hours in patients with mild to moderate hepatic insufficiency due to cirrhosis.

Nephrolithiasis/Urolithiasis
In addition to adequate hydration, medical management in patients who experience nephrolithiasis/urolithiasis may include temporary interruption (e.g. 1-3 days) or discontinuation of therapy.

Dosage modification
Modification in dosage is required when indinavir is co-administered with delavirdine, didanosine, efavirenz, itraconazole, ketoconazole and rifabutin (Consult complete prescribing information)

Contraindications

Indinavir is contraindicated if you have any of the following conditions:
Indinavir-400 is contraindicated in patients with clinically significant hypersensitivity to any of its components.
Indinavir-400 should not be administered concurrently with terfenadine, cisapride, astemizole, triazolam, midazolam, pimozide, or ergot derivatives.

Package

- Container of 30 capsules.
Without Prescription (2017)