Getfitinib

 
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Without a Prescription

Getfitinib belongs to a family of anti-cancer drugs called tyrosine kinase inhibitors.
Getfitinib is a cancer chemotherapy drug which works by blocking a certain protein (an enzyme called tyrosine kinase) which may help cancer grow and spread.
Getfitinib is prescribed alone to treat lung cancer after other cancer chemotherapy treatments have not been successful.
Getfitinib is prescribed as a stand-alone therapy for the continued treatment of advanced non-small cell lung cancer that may or may not have spread (metastasized) to other tissues.
Getfitinib is prescribed for the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Getfitinib is prescribed to treat lung cancer.
Getfitinib is prescribed when treatment with both platinum-based and docetaxel (Taxotere) chemotherapies are ineffective.

Contraindications

Getfitinib is contraindicated if you have any of the following conditions:
- if you have any allergies;
- if you have lung disease (pulmonary fibrosis);
- if you have severe kidney disease;

Interactions

Do not take Getfitinib with any of the following drugs:
- Vinorelbine;
- St John's wort or phenytoin will stimulate certain liver enzymes (CYP 3A4);
- Rifamycins;
- Rifampin;
- Rifabutin;
- Ranitidine;
- Rabeprazole;
- Omeprazole;
- Lansoprazole;
- Ketoconazole;
- Itraconazole;
- Famotidine;
- Erythromycin;
- Drugs which reduce stomach acid;
- CYP 3A4 inhibitors;
- Clarithromycin;
- Cimetidine;
- Certain liver enzyme inhibitors;
- Blood thinners (warfarin);

This CYP3A4 inducer may reduce Getfitinib concentrations and pharmacological effects:
- Talbutal;
- Secobarbital;
- Quinidine barbiturate;
- Primidone;
- Phenytoin;
- Phenobarbital;
- Pentobarbital;
- Methylphenobarbital;
- Methohexital;
- Mephenytoin;
- Hexobarbital;
- Heptabarbital;
- Fosphenytoin;
- Ethotoin;
- Dihydroquinidine barbiturate;
- Carbamazepine;
- Butethal;
- Butalbital;
- Butabarbital;
- Aprobarbital;
- Amobarbital;

Increases the anticoagulant effect:
- Acenocoumarol;
- Anisindione;
- Dicumarol;
- Warfarin;

Increases levels/toxicity of Getfitinib:
- Ritonavir;
- Ketoconazole;
- Itraconazole;
- Erythromycin;
- Clarithromycin;

Side Effects

Getfitinib side effects that you should report to your health care professional or doctor as soon as possible:
- Acne;
- Acne;
- Anorexia (loss of appetite);
- Blood in urine);
- Bloody or black/tarry stool;
- Dark urine;
- Diarrhea;
- Diarrhea;
- Dizziness;
- Dry skin;
- Extreme fatigue;
- Eye irritation/pain;
- feeling of weakness;
- Itching/swelling (especially of the face/tongue/throat);
- itching;
- Loss of appetite;
- Nausea;
- Nausea;
- Rash;
- Rash;
- Red/sore mouth or throat;
- Severe rash;
- Stomach/abdominal pain;
- Swelling of the ankles/feet;
- Trouble breathing;
- Unusual bleeding (coughing up blood;
- Unusual weakness;
- Vomiting;
- Vomiting;
- Weight loss;
- Yellowing eyes/skin;

Overdose

Reported Getfitinib overdose symptoms are:
- Severe skin rash;
- Severe/persistent diarrhea;

Other Brand Names

In some countries Getfitinib may also be known as:
- Getfitinib;
- Tarceva;
- Irressat;
Without Prescription (2017)