Fosinopril

 
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Structure

Fosinopril-10
Each tablet contains Fosinopril sodium 10 mg

Fosinopril-20
Each tablet contains Fosinopril sodium 20 mg

Without a Prescription

Fosinopril is prescribed for: - Hypertension;
- Heart failure;

Dosage

Hypertension
The recommended initial dose of fosinopril is 10 mg once a day, both as monotherapy and when the drug is added to a diuretic.
Dosage should then be adjusted according to blood pressure response at peak (2-6 hours) and trough (about 24 hours after dosing) blood levels.
The usual dosage range needed to maintain a response at trough is 20-40 mg but some patients appear to have a further response to 80 mg.
In some patients treated with once daily dosing, the antihypertensive effect may diminish toward the end of the dosing interval.
If trough response is inadequate, dividing the daily dose should be considered.
If blood pressure is not adequately controlled with fosinopril alone, a diuretic may be added.

Heart Failure
The usual starting dose of fosinopril should be 10 mg once daily.
Following the initial dose of fosinopril, the patient should be observed under medical supervision for at least two hours for the presence of hypotension or orthostasis and, if present, until blood pressure stabilizes.
An initial dose of 5 mg is preferred in heart failure patients with moderate to severe renal failure or those who have been vigorously diuresed.
Dosage should be increased, over a several week period, to a dose that is maximal and tolerated but not exceeding 40 mg once daily.
The usual effective dosage range is 20 to 40 mg once daily.
For Hypertensive or Heart Failure Patients With Renal Impairment In patients with impaired renal function, the total body clearance of fosinoprilat is approximately 50% slower than in patients with normal renal function.
Since hepatobiliary elimination partially compensates for diminished renal elimination, the total body clearance of fosinoprilat does not differ appreciably with any degree of renal insufficiency (creatinine clearances < 80 mL/min/1.73 m2), including end-stage renal failure (creatinine clearance < 10 mL/min/1.73 m2).
This relative constancy of body clearance of active fosinoprilat, resulting from the dual route of elimination, permits use of the usual dose in patients with any degree of renal impairment.

Contraindications

Fosinopril is contraindicated if you have any of the following conditions:
- Hypersensitive to this product or to any other angiotensin converting enzyme inhibitor (e.g., a patient who has experienced angioedema with any other ACE inhibitor therapy).

Package

- Blister of 10 tablets.
Without Prescription (2017)