Eplerenone

 
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Without a Prescription

Eplerenone belongs to a family of drugs called aldosterone antagonists.
Eplerenone is prescribed alone or in combination with other medicines to treat high blood pressure.
Eplerenone is prescribed for improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.
Eplerenone is prescribed for the treatment of congestive heart failure (CHF) in people after they have had a heart attack (acute myocardial infarction, or "MI").
Eplerenone is prescribed for the treatment of hypertension (high blood pressure).
Eplerenone is prescribed to treat congestive heart failure following a heart attack.
Eplerenone is prescribed to treat patients with congestive heart failure (CHF) and high blood pressure (hypertension).
Eplerenone works by blocking a chemical (aldosterone) in your body which in turn lowers the amount of sodium and water the body retains.
Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.

Contraindications

Eplerenone is contraindicated if you have any of the following conditions:
- if you are allergic to Eplerenone;
- if you have any other allergies;
- if you have diabetes;
- if you have high potassium blood levels (hyperkalemia);
- if you have severe kidney disease;
Eplerenone can cause hyperkalemia (high blood potassium levels). Signs of hyperkalemia include:
- Heart palpitation;
- Malaise (feeling tired);
- Muscle weaknes;

Interactions

Do not take Eplerenone with any of the following drugs:
- ACE inhibitors;
- Amiloride;
- Angiotensin II blockers;
- Azole antifungals;
- Captopril;
- Certain "water pills";
- Clarithromycin;
- Enalapril;
- Erythromycin;
- Fluconazole;
- Ibuprofen;
- Indomethacin;
- Itraconazole;
- Ketoconazole;
- Lithium;
- Losartan;
- Macrolide antibiotics;
- Naproxen;
- Nefazodone;
- Nelfinavir;
- Nonsteroidal anti-inflammatory drugs;
- NSAIDs;
- Potassium supplements;
- Potassium-sparing types;
- Protease inhibitors;
- Ritonavir;
- Saquinavir;
- Spironolactone;
- St John's wort;
- Triamterene;
- Valsartan;
- Verapamil;

This association presents an increased risk of hyperkaliemia:
- Amiloride;
- Potassium;
- Spironolactone;
- Triamterene;

This macrolide increases the effect and toxicity of Eplerenone:
- Clarithromycin;
- Erythromycin;
- Fluconazole;
- Itraconazole;
- Ketoconazole;
- Lithium;
- Nefazodone;
- Nelfinavir;
- Polystyrene sulfonate;
- Ritonavir;
- Saquinavir;
- Troleandomycin;
- Verapamil;

Side Effects

Eplerenone side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Abnormal vaginal bleeding;
- Albuminuria (increased levels of the blood protein albumin excreted in the urine);
- Chills;
- Cough or flu-like symptoms;
- Coughing;
- Diarrhea;
- Dizziness;
- Enlarged or sore breasts in males;
- Fatigue;
- Fever;
- Flu-like symptoms;
- Headache;
- Hypercholesterolemia (high blood cholesterol levels);
- Hypertriglyceridemia (high blood lipid levels);
- Itching/swelling (especially of the face/tongue/throat);
- Nausea;
- Rash;
- Severe dizziness;
- Stomach pain;
- Trouble breathing;
- Unusual tiredness;

Overdose

Reported Eplerenone overdose symptoms are:
- Severe muscle weakness;
- Severe dizziness;
- Irregular heartbeat;
Without Prescription (2017)