Without a Prescription

Eldepryl is a substance known as a neurotransmitter. Neurotransmitters are present in the brain and nervous system and are involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced or absent in the brains of people with Parkinson's disease, and this is thought to be the cause of the disease symptoms. The mainstay of treating Parkinson's disease is to replace dopamine in the brain.
Eldepryl is prescribed along with Sinemet (levodopa/carbidopa) for people with Parkinson's disease. It is prescribed when Sinemet no longer seems to be working well. Eldepryl has no effect when taken by itself it works only in combination with Larodopa (levodopa) or Sinemet.
Eldepryl is prescribed for the treatment of Parkinson's disease.
Eldepryl may be prescribed at this stage of the disease to help restore the effectiveness of Larodopa or Sinemet. When you begin to take Eldepryl, you may need a reduced dosage of the other medication.
Eldepryl tablets and syrup contain the active ingredient selegiline hydrochloride, which is a type of drug called a selective monoamine-oxidase-B inhibitor. Selegiline is available without a brand name, ie as the generic drug. Selegiline increases the levels of a substance in the brain called dopamine, and is prescribed in the treatment of Parkinson's disease.
Natural dopamine released from nerve cells in the brain is normally broken down by an enzyme called monoamine-oxidase-B. Selegiline works by blocking the action of this enzyme, which prevents the monoamine-oxidase-B from breaking down the dopamine. This results in an increased amount of active dopamine in the brain, and this reduces the symptoms of Parkinson's disease.
Parkinson's disease, which causes muscle rigidity and difficulty with walking and talking, involves the progressive degeneration of a particular type of nerve cell. Early on, Larodopa or Sinemet alone may alleviate the symptoms of the disease. In time, however, these medications work less well their effectiveness seems to switch on and off at random, and the individual may begin to experience side effects such as involuntary movements and "freezing" in mid-motion.
Selegiline is usually prescribed in combination with a drug called levodopa to treat Parkinson's disease. Levodopa is converted into dopamine in the brain and therefore works by directly replacing the lost dopamine. Unfortunately, levodopa treatment tends to become less effective over time and patients tend to experience 'end-of-dose' deterioration, where the duration of benefit after each dose of levodopa becomes progressively shorter. Selegiline can be prescribed to prolong the effect of levodopa, because it stops the dopamine that is formed from the levodopa from being broken down in the brain. This extends the action of levodopa thereby reducing the 'end-of-dose' side effects.

Side Effects

Eldepryl side effects that you should report to your health care professional or doctor as soon as possible:
- A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness;
- Abdominal pain;
- Agitation;
- Alteration in results of liver function tests;
- Balance problems involving the inner ear;
- Confusion;
- Difficulty in passing urine;
- Disturbed sleep;
- Dizziness;
- Dry mouth;
- Fainting;
- Hallucinations;
- Headache;
- Lightheadedness;
- Mouth ulcers;
- Nausea and vomiting;
- Nausea;
- Skin reactions such as rash and itch;



The use of Eldepryl in children has not been evaluated.


There is no evidence of additional benefit from higher doses, and they increase the risk of side effects.
The recommended dose of Eldepryl is 10 mg per day divided into 2 smaller doses of 5 mg each, taken at breakfast and lunch.
Without Prescription (2017)