Without a Prescription
Diflunisal is prescribed for the treatment of inflammation and pain that results from many forms of arthritis, including rheumatoid arthritis and Osteoarthritis, as well as soft tissue injuries, such as tendinitis, and bursitis. Diflunisal is immediately released into the blood and is also prescribed for rapid relief of mild to moderate pain and menstrual cramps.
Diflunisal should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with Peptic ulcer disease or poor kidney function, since Diflunisal can aggravate both conditions. Diflunisal is generally prescribed with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of increased risk of bleeding. Patients also taking cyclosporine (Sandimmune) can develop kidney toxicity. It is not recommended in children under 12 years of age. Diflunisal is not habit forming. NSAIDs should be discontinued prior to elective surgery because of a mild tendency to interfere with blood clotting. Diflunisal is best discontinued at least five days in advance of the procedure. Persons who have excessive alcoholic intake are at increased risk of developing stomach ulcers when taking Diflunisal or other NSAIDs. Diflunisal is generally avoided during pregnancy in nursing mothers.
The most common side effects of Diflunisal involve the gastrointestinal system. It can cause ulcerations, abdominal burning, pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding and liver toxicity. Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness are also seen
If overdose is suspected, contact your local poison control center or emergency room immediately.
Store Diflunisal at room temperature and out of reach of children. It should be taken with food.
Other Brand Names
In some countries Diflunisal may also be known as: