Cefepime

 
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Structure

Cefepime - 0.5 gm
Each vial contains Cefepime Hydrochloride Monohydrate equivalent to Cefepime 0.5 gm; Excipient : L-arginine

Cefepime - 1 gm
Each vial contains Cefepime Hydrochloride Monohydrate equivalent to Cefepime 1 gm, Excipient: L-arginine

Cefepime - 2 gm
Each vial contains Cefepime Hydrochloride Monohydrate equivalent to Cefepime 2 gm, Excipient: L-arginine

Cefepime - 0.5 gm is available in a vial of 10 ml with 5 ml Sterile water for injection IP

Cefepime - 1 gm is available in a vial of 15 ml with 10 ml Sterile water for injection IP

Cefepime - 2 gm is available in a vial of 20 ml with 10 ml Sterile water for injection IP

Without a Prescription

Cefepime hydrochloride is prescribed in the treatment of the following infections caused by susceptible strains of the designated microorganisms:

Pneumonia (moderate to severe) caused by Streptococcus pneumoniae, including cases associated with concurrent bacteremia, Pseudomonas aeruginosa, Klebsiella pneumoniae, or Enterobacter species.

Empiric Therapy for Febrile Neutropenic Patients. Cefepime as mono-therapy is prescribed for empiric treatment of febrile neutropenic patients.
In patients at high risk for severe infection (including patients with a history of recent bone marrow transplantation, with hypotension at presentation, with an underlying hematologic malignancy, or with severe or prolonged neutropenia), antimicrobial monotherapy may not be appropriate.
Insufficient data exist to support the efficacy of cefepime monotherapy in such patients.

Uncomplicated and Complicated Urinary Tract Infections (including pyelonephritis) caused by Escherichia coli or Klebsiella pneumoniae, when the infection is severe, or caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis, when the infection is mild to moderate, including cases associated with concurrent bacteremia with these microorganisms.

Uncomplicated Skin and Skin Structure Infections caused by Staphylococcus aureus (methicillin-susceptible strains only) or Streptococcus pyogenes.

Complicated Intra-abdominal Infections (used in combination with metronidazole) caused by Escherichia coli, viridans group streptococci, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter species, or Bacteroides fragilis.

Dosage

The recommended adult dosages and routes of administration are outlined in the following table.
Cefepime should be administered intravenously over approximately 30 minutes.

Impaired Hepatic Function- No adjustment is necessary for patients with impaired hepatic function.
Impaired Renal Function- In patients with impaired renal function (creatinine clearance adjusted to compensate for the slower rate of renal elimination.
The recommended initial dose of Cefepime should be the same as in patients with normal renal function.
The recommended maintenance doses of Cefepime in patients with renal insufficiency are presented in the table below.

Contraindications

Cefepime is contraindicated if you have any of the following conditions:
Cefepime hydrochloride is contraindicated in patients who have shown immediate hypersensitivity reactions to cefepime or the cephalosporin class of antibiotics, penicillins or other beta-lactam antibiotics.
Without Prescription (2017)