Without a Prescription

Aciphex blocks acid production in the stomach.
This condition, known as gastroesophageal reflux disease (GERD), is caused by the backflow of stomach acid into the esophagus over a prolonged period of time.
The drug is classified as a "proton pump inhibitor."
It works by blocking a specific enzyme essential to the production of stomach acid. It begins reducing acid within an hour of administration.
It is prescribed for the short-term (4 to 8 weeks) treatment of sores and inflammation in the upper digestive canal (esophagus).
For that reason, doctors are warned to rule out cancer whenever prescribing this drug.
Because GERD can be chronic, your doctor may continue to prescribe Aciphex to prevent a relapse after your initial course of treatment and to relieve symptoms of GERD such as heartburn.
Aciphex will work even if your symptoms are caused by a serious condition such as stomach cancer.
Aciphex can be prescribed for the short-term (up to 4 weeks) treatment of duodenal ulcers (ulcers that form just outside the stomach at the top of the small intestine), and for Zollinger-Ellison syndrome, a disease which causes the stomach to produce too much acid.

Side Effects

Aciphex side effects that you should report to your health care professional or doctor as soon as possible:

Headache is the most common side effect of Aciphex, striking two people out of 100.

Less common side effects may include:
- Mouth inflammation;
- Migraine;
- Lymph node disease;
- Loss of appetite;
- Leg cramps;
- Laryngitis;
- Kidney stone;
- Joint disease;
- Itching;
- Irregular heartbeat;
- Intestinal inflammation;
- Insomnia;
- Inflammation of the pancreas;
- Inflammation of the esophagus;
- Increased appetite;
- Hyperventilation;
- Hives;
- High blood pressure;
- Hiccup;
- Heart attack;
- Hair loss;
- Gum inflammation;
- Gout;
- Glaucoma;
- Gas;
- Gallbladder disease;
- Frequent urination;
- Fluid retention;
- Fever;
- Fatigue;
- Fainting;
- Ear infection;
- Dry mouth;
- Dry eyes;
- Dizziness;
- Difficult periods;
- Difficult breathing;
- Diarrhea;
- Depression;
- Dehydration;
- Decreased sex drive;
- Convulsion;
- Constipation;
- Chills;
- Chest pain;
- Cataract;
- Bursitis;
- Bruising;
- Breakthrough menstrual bleeding;
- Bone pain;
- Bladder inflammation;
- Belching;
- Asthma;
- Arthritis;
- Anxiety;
- Allergic reaction;
- Abnormal vision;
- Abnormal stools;
- Abnormal dreams;
- Abdominal pain;

Rare side effects may include:
- Visual disturbance;
- Vein inflammation;
- Vaginal discharge;
- Urinary incontinence;
- Twitching;
- Thirst;
- Testicular inflammation;
- Stomach bleeding;
- Slowed breathing;
- Skin discoloration or scaling;
- Shingles;
- Salivary gland enlargement;
- Nervous disorders;
- Liver disorders;
- Irregular heartbeat;
- Intestinal bleeding;
- Inflammation of the small intestine;
- Impotence;
- Hyperactivity;
- Heavy periods;
- Hangover effect;
- Fluid retention of the face;
- Eye pain;
- Dry skin;
- Deafness;
- Confusion;
- Breast enlargement;
- Bloody diarrhea;
- Blood vessel enlargement;
- Blood in the urine;
- Blood clot;
- Bile duct inflammation;
- Amnesia;
- Agitation;
- Absence of breathing;
- Abdominal swelling;


Aciphex is contraindicated if you have any of the following conditions:
- If Aciphex gives you an allergic reaction;
- If you have stomach ulcers caused by the h. pylori bacteria;


Do not take Aciphex with any of the following drugs:
- Warfarin (coumadin);
- Ketoconazole (nizoral);
- Digoxin (lanoxin);
- Cyclosporine (neoral, sandimmune);



Zollinger-Ellison Syndrome

Doses of up to 100 milligrams once a day or 60 milligrams twice a day are sometimes prescribed.
The usual starting dose is 60 milligrams once a day, although your doctor may adjust the dose based on your individual need.

Gastroesophageal Reflux Disease (GERD)

For patients who have not healed after 8 weeks, the doctor may prescribe an additional 8-week course of Aciphex therapy.
The usual dose is 20 milligrams once a day for 4 to 8 weeks.

Duodenal Ulcer

Some people may require an additional 4 weeks of treatment.
The usual dose is 20 milligrams taken once daily after the morning meal for a period of up to 4 weeks.

To Relieve Symptoms or Prevent a Relapse of GERD

The usual dose is 20 milligrams once a day.


Little is known about Aciphex overdose. However, any medication taken in excess can have serious consequences.
If you suspect an overdose, seek medical attention immediately.
Without Prescription (2017)